https://blog.wongcw.com/2023/03/18/%e5%ae%8c%e5%96%84%e7%9a%84crispr%e7%b3%bb%e7%b5%b1%e4%bd%bf%e5%b0%8f%e9%bc%a0%e7%9a%84%e8%a6%96%e5%8a%9b%e5%be%97%e5%88%b0%e6%81%a2%e5%be%a9/