https://blog.wongcw.com/2021/12/09/%e5%b0%8d%e6%8a%97%e8%82%9d%e7%99%8c%e7%9a%84%e6%96%b0%e7%b5%84%e5%90%88%ef%bc%9acrispr%e5%9f%ba%e5%9b%a0%e7%99%82%e6%b3%95%e3%80%81%e8%b6%85%e8%81%b2%e6%b3%a2%e5%92%8c%e8%97%a5%e7%89%a9/