https://blog.wongcw.com/2021/11/01/%e5%9f%ba%e5%9b%a0%e7%b7%a8%e8%bc%af%e5%85%88%e9%a9%85%e7%98%8b%e7%8b%82%e8%a8%88%e5%8a%83%ef%bc%9a6%e5%b9%b4%e5%85%a7%e3%80%8c%e5%be%a9%e6%b4%bb%e3%80%8d%e7%8c%9b%e7%8d%81%ef%bc%8c%e7%94%a8crispr/