https://blog.wongcw.com/2021/07/15/%e7%a0%94%e7%a9%b6%e4%ba%ba%e5%93%a1%e5%89%b5%e9%80%a0%e6%96%b0%e7%9a%84crispr%e5%9f%ba%e5%9b%a0%e5%b7%a5%e5%85%b7%e5%b9%ab%e5%8a%a9%e9%81%8f%e5%88%b6%e8%9a%8a%e5%aa%92%e5%82%b3%e6%9f%93%e7%97%85/