https://blog.wongcw.com/2018/12/15/%e6%b8%9b%e8%82%a5%e7%a5%9e%e5%99%a8%e4%be%86%e4%ba%86%e7%a7%91%e5%ad%b8%e5%ae%b6%e9%96%8b%e7%99%bc%e6%96%b0%e5%9e%8bcrispr%e7%b3%bb%e7%b5%b1%e6%b2%bb%e7%99%82%e8%82%a5%e8%83%96%e7%97%87/